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Week 1 NFL Best Bets

1. Buffalo Bills -2.5 vs. Los Angeles Rams

The Bills are the consensus Super Bowl favorite this season, and they open the season with a home game against the Rams, who are without Matthew Stafford and Cooper Kupp. Buffalo has a top-five defense and an offense led by Josh Allen, Stefon Diggs, and Gabriel Davis. The Rams are a shell of their former selves, and the Bills should win this game handily.

2. Kansas City Chiefs -6 vs. Arizona Cardinals

The Chiefs are another Super Bowl contender, and they open the season with a home game against the Cardinals, who are coming off a disappointing season. Kansas City has a high-powered offense led by Patrick Mahomes, Tyreek Hill, and Travis Kelce. The Cardinals have a solid defense, but they will be without DeAndre Hopkins for the first six games of the season. The Chiefs should win this game by at least a touchdown.

3. Cincinnati Bengals +7 vs. Pittsburgh Steelers

The Bengals are coming off a Super Bowl appearance, and they open the season with a road game against the Steelers, who are in a rebuilding mode. Cincinnati has a young and talented team led by Joe Burrow, Ja'Marr Chase, and Tee Higgins. The Steelers have a solid defense, but their offense is a major question mark. The Bengals should be able to cover the spread in this game.

4. Baltimore Ravens -3.5 vs. New York Jets

The Ravens are a dark horse Super Bowl contender, and they open the season with a home game against the Jets, who are one of the worst teams in the NFL. Baltimore has a top-10 defense and an offense led by Lamar Jackson, Mark Andrews, and Rashod Bateman. The Jets are a young and inexperienced team, and they should be no match for the Ravens.

5. Philadelphia Eagles -6.5 vs. Detroit Lions

The Eagles are a rising team, and they open the season with a home game against the Lions, who are one of the worst teams in the NFL. Philadelphia has a solid defense and an offense led by Jalen Hurts, A.J. Brown, and DeVonta Smith. The Lions have a lot of young talent, but they are still a few years away from being a competitive team. The Eagles should win this game by at least a touchdown.

6. New Orleans Saints -5.5 vs. Atlanta Falcons

The Saints are a veteran team with a lot of talent, and they open the season with a home game against the Falcons, who are in a rebuilding mode. New Orleans has a top-10 defense and an offense led by Jameis Winston, Alvin Kamara, and Michael Thomas. The Falcons have a young and inexperienced team, and they should be no match for the Saints.

7. Jacksonville Jaguars +3 vs. Washington Commanders

The Jaguars are a young and improving team, and they open the season with a home game against the Commanders, who are a middle-of-the-pack team. Jacksonville has a lot of young talent on both sides of the ball, and they should be able to compete with Washington. The Commanders have a solid defense, but their offense is a major question mark. The Jaguars should be able to cover the spread in this game.

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